Intra-articular extra-axial chordoma of the wrist: a case report with review of the current literature
- 18 May 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Skeletal Radiology
- Vol. 48 (12), 2015-2020
- https://doi.org/10.1007/s00256-019-03228-7
Abstract
Chordomas are rare bone malignancies that are thought to arise from remnants of the notochord and usually are located in the axial skeleton. Immunophenotypical matching neoplasms primarily found in appendicular locations, referred to as extra-axial chordoma, are rarely encountered by radiologists, surgeons, and pathologists. Only a few of these cases have been described in the literature with only one intra-articular case with involvement of the knee joint. We present the first case of an intra-articular extra-axial chordoma of the wrist. Diagnostic imaging patterns were initially ambiguous and histopathological reprocessing was crucial in order to determine the diagnosis of an intra-articular neoplasm with co-expression of cytokeratins, S-100 protein, and brachyury.Keywords
This publication has 23 references indexed in Scilit:
- Recurrent skeletal extra-axial chordoma confirmed with brachyury: Imaging features and review of the literatureSkeletal Radiology, 2013
- Extra-axial soft tissue chordoma of wristPathology - Research and Practice, 2011
- Brachyury Expression in Extra-axial Skeletal and Soft Tissue Chordomas: A Marker that Distinguishes Chordoma From Mixed Tumor/Myoepithelioma/Parachordoma in Soft TissueThe American Journal of Surgical Pathology, 2008
- Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisationBritish Journal of Cancer, 2007
- Chordoma and chondrosarcoma: Similar, but quite different, skull base tumorsCancer, 2007
- Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiationSkeletal Radiology, 2006
- Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomasThe Journal of Pathology, 2006
- Structure and function of the notochord: an essential organ for chordate developmentDevelopment, 2005
- Parachordoma is not distinguishable from axial chordoma using immunohistochemistryPathology International, 2004
- Demonstration of cytokeratins and an epithelial membrane antigen in chordomas and human fetal notochordThe American Journal of Surgical Pathology, 1985