Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and Adolescents
Open Access
- 1 December 2021
- journal article
- research article
- Published by Galenos Yayinevi in Journal of Clinical Research in Pediatric Endocrinology
- Vol. 13 (4), 426-432
- https://doi.org/10.4274/jcrpe.galenos.2021.2021.0047
Abstract
Objective:The aim of this study was to evaluate the efficiency of a buccal spray form of vitamin D compared to single oral dose (stoss therapy) and oral drops therapy in the treatment of vitamin D deficiency.Methods:Ninety healthy children and adolescents (3-18 years) with vitamin D deficiency [serum level of 25-hydroxyvitamin D (25(OH) D) <12 ng/mL] were randomized to receive vitamin D3 buccal spray (2000 U, n=30, group 1) for six weeks, oral drops (2000 U, n=30, group 2) for six weeks and a single oral dose (300 000 U) vitamin D3 (n=30, group 3). Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25(OH)D levels of the patients were measured at baseline and after the treatment on the 42nd day.Results:All three groups had a significant increase in serum 25(OH)D concentrations (p<0.001). In group 1, baseline mean 25(OH)D was 8.0±0.41 ng/mL, which rose to 22.1 (17.8-28.2) ng/mL after treatment with a mean increase of 15.6±1.3 ng/mL. Similarly in group 2, baseline, post-treatment and mean increase in 25(OH)D concentrations were 7.9±0.45 ng/mL, 24.4 (20.6-29.6) ng/mL and 17.3±1.1 ng/mL while for group 3 these values were 7.6±0.47 ng/mL, 40.3 (29.4-58.4) ng/mL and 34.3±3.2 ng/mL, respectively.Conclusion:We conclude that vitamin D3 supplementation with buccal spray and oral drops is equally effective in terms of raising vitamin D concentrations in short-term treatment of vitamin D deficiency.Keywords
This publication has 29 references indexed in Scilit:
- Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studiesProceedings of the Nutrition Society, 2012
- Treatment of Vitamin D Insufficiency in Children and Adolescents with Inflammatory Bowel Disease: A Randomized Clinical Trial Comparing Three RegimensJournal of Clinical Endocrinology & Metabolism, 2012
- Plasma 25-Hydroxyvitamin D and Progression to Diabetes in Patients at Risk for DiabetesDiabetes Care, 2012
- Vitamin D and type 2 diabetes: a systematic reviewEuropean Journal of Clinical Nutrition, 2011
- Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare PopulationThe American Journal of Cardiology, 2010
- Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and AdolescentsPEDIATRICS, 2008
- Vitamin D and multiple sclerosisJournal of Cellular Biochemistry, 2008
- Treatment of Hypovitaminosis D in Infants and ToddlersJournal of Clinical Endocrinology & Metabolism, 2008
- Reference Body Mass Index Curves for Turkish Children 6 to 18 Years of AgeJournal of Pediatric Endocrinology and Metabolism, 2008
- Vitamin D Status in Children and Young Adults With Inflammatory Bowel DiseasePEDIATRICS, 2006