The pre-metastatic niche in lymph nodes: formation and characteristics
Open Access
- 9 July 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 78 (16), 5987-6002
- https://doi.org/10.1007/s00018-021-03873-z
Abstract
Lymph node metastasis is a crucial prognostic parameter in many different types of cancers and a gateway for further dissemination to distant organs. Prior to metastatic dissemination, the primary tumor prepares for the remodeling of the draining (sentinel) lymph node by secreting soluble factors or releasing extracellular vesicles that are transported by lymphatic vessels. These important changes occur before the appearance of the first metastatic cell and create what is known as a pre-metastatic niche giving rise to the subsequent survival and growth of metastatic cells. In this review, the lymph node structure, matrix composition and the emerging heterogeneity of cells forming it are described. Current knowledge of the major cellular and molecular processes associated with nodal pre-metastatic niche formation, including lymphangiogenesis, extracellular matrix remodeling, and immunosuppressive cell enlisting in lymph nodes are additionally summarized. Finally, future directions that research could possibly take and the clinical impact are discussed.Keywords
Funding Information
- Fonds De La Recherche Scientifique - FNRS (Télévie, Télévie)
- Fondation contre le Cancer
- Fonds Léon Fredericq
- Fédération Wallonie-Bruxelles (1610119, A.R.C. 19/23-21)
This publication has 179 references indexed in Scilit:
- PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodesProceedings of the National Academy of Sciences of the United States of America, 2013
- Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarksNature Immunology, 2012
- VEGF-A and Tenascin-C produced by S100A4 + stromal cells are important for metastatic colonizationProceedings of the National Academy of Sciences of the United States of America, 2011
- CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated AntigensImmunity, 2011
- The metastatic niche: adapting the foreign soilNature Reviews Cancer, 2009
- Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node FolliclesImmunity, 2009
- Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic NicheCancer Cell, 2009
- Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in miceNature, 2007
- Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancerNature Medicine, 2007
- Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trialThe Lancet, 1998