Abstract
Work begins from a large historical background the emergence of the doctrine of immunoglobulins. A brief review of the development of world achievements in the use of immunoglobulin therapy is given. We give the rationale for the treatment of various human diseases in situations of ineffective protocol treatment, the principles of searching for the etiology and making the correct diagnosis. Often a visit to an immunologist is the only hope of the patient in solving the health problem. Several cases from hundreds of patients observed by us are described. All medical professionals working according to the protocols themselves should be referred to the immunologist in cases of lack of diagnosis or ineffective treatment. Treatment of patients should begin with the establishment of an etiological factor in any disease, even in cases of oncology. Until the root cause of the disease has been identified, treatment cannot be effective. The use of immunoglobulin therapy has no contraindications, and its effectiveness and safety are presented in the work.

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