According to several research reports, by the year 2005 there will be over 700 million worldwide users on the Internet. This will represent over 10% of the World’s population. Furthermore, data indicates that in 1999 business users comprised 54% of all Internet users. Of importance to technology transfer providers is that the number of small businesses using the Internet is growing daily. During the past few decades, we have seen national economies move from industrial to information to global knowledge-based systems. The technical drivers have been primarily personal computers, information technologies and the Internet. Technological innovation and technology transfer are driving this transition. Electronic commerce (E-commerce) is growing significantly and is now involving technology transfer. Managers of many dotcoms believe that successful technology transfer and commercialization (TT) can be increased many times the current rate via E-commerce. Presently there exist a few thousand TT web sites. However, there are only a handful of technology transfer E-commerce sites on-line. It is quite possible that E-commerce may become the new paradigm for TT. However many factors have yet to be determined. For example, what is the appropriate TT Ebusiness model, what will be the economic impact, what will adoption of Ecommerce mean for TT professionals, will money be made for investors and owners of technologies? This paper is a framework for beginning to examine these issues.