Hydrophilic gold nanospheres: influence of alendronate, memantine, and tobramycin on morphostructural features
Open Access
- 22 November 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Chemistry
- Vol. 16 (1), 1-15
- https://doi.org/10.1186/s13065-022-00891-1
Abstract
Turkevich gold nanospheres are the original nanospheres that have been modified over time. Its combination with targeting medications such as alendronate, memantine, and tobramycin will provide additional benefits in targeting specific areas in the bone, brain, and microorganisms, respectively. Hence, The reactivity and stability of nanospheres with various drug concentrations (milli-,micro-, and nano-levels) have been studied. With alendronate, the absorbance spectra of nanospheres at \(\uplambda _{max}\) 520 nm were always stable and no redshifts occurred. In contrast, the spectra with memantine and tobramycin were stable at the nano-level and redshifts occurred at the milli- and micro-levels. HRTEM and DLS revealed that the core diameter was relatively stable in all cases, whereas the hydrodynamic diameter and zeta potential varied with varying drug concentrations. Increasing concentration increased hydrodynamic diameter slightly with memantine (from 64.99 to 98.41 nm), dramatically with tobramycin (from 135.3 to 332.16 nm), and almost negligibly with alendronate (from 52.08 to 58.94 nm ). Zeta Potential, conversely, is reduced as concentration increases. Memantine had the greatest reduction in negativity, followed by tobramycin, but alendronate had a slight increase in negativity. Benefits from this research would be in targeted drug delivery, where stability and reactivity of gold nanospheres are critical.
Keywords
Funding Information
- Ministry of Health and Population
This publication has 33 references indexed in Scilit:
- Multiple strategies to activate gold nanoparticles as antibioticsNanoscale, 2013
- Alendronate SodiumProfiles of Drug Substances, Excipients and Related Methodology, 2013
- Gold nanoparticle platforms as drug and biomacromolecule delivery systemsJournal of Controlled Release, 2010
- Facile strategy for stability control of gold nanoparticles synthesized by aqueous reduction methodCurrent Applied Physics, 2010
- Design and fabrication of magnetic nanoparticles for targeted drug delivery and imagingAdvanced Drug Delivery Reviews, 2010
- The Chemistry of GoldPublished by Wiley ,2008
- Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle BiodistributionMolecular Pharmaceutics, 2008
- Extinction coefficient of gold nanoparticles with different sizes and different capping ligandsColloids and Surfaces B: Biointerfaces, 2007
- Memantine: update on the current evidenceInternational Journal of Geriatric Psychiatry, 2003
- TobramycinAnalytical Profiles of Drug Substances and Excipients, 1996