Objective: To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology. Methods: Retrospective exhibition of these patients' clinical characters included undergoing diseases, infectious organs, history illness, blood glucose and glycosylated hemoglobin (HbA1C), biochemical indicators, pathogens training description and results, medical imagines, antibiotic utilization, length of stay and hospital costs, final diagnosis and situations. Results: Non-diabetic patients accounted for 176 (21.67%), who were the cases of untreated well hyperthyroidism, mainly suffered with respiratory tract infection. Diabetic patients accounted for 636 (78.33%). In the type2 diabetes patients 376 (59.12) suffered with urinary tract infection. 192 (30.19%) suffered with respiratory system infection, 124 (19.50%) were accompanied with diabetic foot infection, which had 74 (59.67%) patients with HbA1C＞9.0%.Statistical comparisons showed that the days of antibiotic use and average length of stay in hospital per capita in patients with HbA1C≥8% were more than ones with HbA1C＜8% in those with diabetic infections (P＜0.01) . The days of antibiotic use per capita in patients with HbA1C＞9% were more than ones with HbA1C＜7% in those with diabetic foot infections (P＜0.01). Conclusion: Endocrine diseases lack rigid and effective long-term control, which may result in the complications involved with urinary tract, respiratory tract and infections in other organs. The time of hospitalization per capita and the duration of antibiotic use rise are longer in diabetic patients with poor blood sugar control and diabetic foot infection.