Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression
Open Access
- 27 September 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Psychiatry
- Vol. 22 (1), 1-12
- https://doi.org/10.1186/s12888-022-04255-w
Abstract
The pathophysiological mechanisms of aggression are manifold and they may closely interconnect. Current study aimed to determine the gut microbiota and its metabolites, and clarify their correlations with inflammation, oxidation, leaky gut and clinical profiles underlying aggression in schizophrenia (ScZ). Serum and stool specimens from ScZ inpatients with (ScZ-Ag, 25 cases) and without aggression (NScZ-Ag, 25 cases) were collected. Systemic inflammation, oxidation and leaky gut biomarkers were determined by ELISA, gut microbiota by 16S rRNA sequencing, short-chain fatty acids (SCFAs) by gas chromatography-mass spectrometry analysis and neurotransmitters by liquid chromatograph mass spectrometry analysis. Significantly higher systemic pro-inflammation, pro-oxidation and leaky gut biomarkers were observed in ScZ-Ag than NScZ-Ag group (all PPrevotella was significantly increased, while that Bacteroides, Faecalibacterium, Blautia, Bifidobacterium,Collinsella and Eubacterium_coprostanoligenes were remarkably reduced in ScZ-Ag group (all corrected PP<0.05). Finally, a few strongly positive or negative correlations among altered gut microbiota, SCFAs, systemic pro-inflammation, leaky gut, pro-oxidation and aggression severity were detected. These results demonstrate that pro-inflammation, pro-oxidation and leaky gut phenotypes relating to enteric dysbacteriosis and microbial SCFAs feature the aggression onset or severity in ScZ individuals.This publication has 41 references indexed in Scilit:
- Gut microbiota, metabolites and host immunityNature Reviews Immunology, 2016
- Formation of short chain fatty acids by the gut microbiota and their impact on human metabolismGut Microbes, 2016
- Childhood trauma and parental style: Relationship with markers of inflammation, oxidative stress, and aggression in healthy and personality disordered subjectsBiological Psychology, 2015
- Prevalence of aggression in hospitalized patients with schizophrenia in China: A meta‐analysisAsia-Pacific Psychiatry, 2015
- On the use of the Positive and Negative Syndrome Scale in randomized clinical trialsSchizophrenia Research, 2015
- Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune DysregulationClinical Therapeutics, 2015
- Verbal versus physical aggression in Intermittent Explosive DisorderPsychiatry Research, 2014
- Elevated Plasma Oxidative Stress Markers in Individuals With Intermittent Explosive Disorder and Correlation With Aggression in HumansBiological Psychiatry, 2014
- Pro-inflammatory Prevotella?Nature Reviews Microbiology, 2013
- Subtypes of aggression in patients with schizophrenia: The role of personality disordersCriminal Behaviour and Mental Health, 2013