Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties
Open Access
- 18 September 2020
- Vol. 25 (18), 4294
- https://doi.org/10.3390/molecules25184294
Abstract
Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.Funding Information
- National Research Foundation of Korea (2017R1A6A1A03015642)
This publication has 60 references indexed in Scilit:
- Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedaeMolecules, 2013
- Maturation and function of human dendritic cells are regulated by B lymphocytesBlood, 2012
- Medicinal Plants Used as Antitumor Agents in Brazil: An Ethnobotanical ApproachEvidence-Based Complementary and Alternative Medicine, 2011
- Oxidative stress, inflammation, and cancer: How are they linked?Free Radical Biology & Medicine, 2010
- Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trialColorectal Disease, 2010
- Role of interleukin-1β during pain and inflammationBrain Research Reviews, 2009
- Tropical American Plants in the Treatment of Infectious DiseasesJournal of Dietary Supplements, 2008
- Potential Antipsoriatic Agents: Lapacho Compounds as Potent Inhibitors of HaCaT Cell GrowthJournal of Natural Products, 1999
- Growth inhibition of estrogen receptor positive human breast cancer cells by Taheebo from the inner bark of Tabebuia avellandae treeInternational Journal of Molecular Medicine, 1998
- A new naphthaquinone from Tabebuia guayacanPhytochemistry, 1976