Extra Chromosomal Circular DNA: Recent Advances in Research
- 1 April 2022
- journal article
- Published by SciRes Literature LLC in Journal of Biomedical Research & Environmental Sciences
- Vol. 3 (4), 445-452
- https://doi.org/10.37871/jbres1463
Abstract
Extrachromosomal circular DNA (eccDNA) is a circular DNA molecule outside of eukaryotic staining, in which DNA forms in the genome or exogenous DNA in the cell. eccDNA is a special class of genetic material that can carry complete genes encoding functional proteins or RNA. Studies have shown that eccDNA can participate in various physiological and pathological processes in a special way, such as aging and the occurrence of tumors. This paper reviews the latest research progress of eccDNA and further expounds on the relationship between eccDNA and tumors.Keywords
This publication has 65 references indexed in Scilit:
- Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficienciesJournal of Translational Medicine, 2013
- Age-associated DNA methylation in pediatric populationsGenome Research, 2012
- Origin-Dependent Inverted-Repeat Amplification: A Replication-Based Model for Generating Palindromic AmpliconsPLoS Genetics, 2011
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer DevelopmentCell, 2011
- Discovering DNA: Friedrich Miescher and the early years of nucleic acid researchHuman Genetics, 2007
- Finely Orchestrated Movements: Evolution of the Ribosomal RNA GenesGenetics, 2007
- The taming of a transposon: V(D)J recombination and the immune systemImmunological Reviews, 2004
- Extrachromosomal Circular DNA of Tandemly Repeated Genomic Sequences in DrosophilaGenome Research, 2003
- Extrachromosomal rDNA Circles— A Cause of Aging in YeastCell, 1997
- MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOODThe Lancet, 1965