The association between metabolic syndrome and successful aging- using an extended definition of successful aging
Open Access
- 30 November 2021
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 16 (11), e0260550
- https://doi.org/10.1371/journal.pone.0260550
Abstract
To examine the association between metabolic syndrome (MetS) and successful aging among community-dwelling older adults. Adults aged ≥ 65 years who participated in the senior health checkup program at National Taiwan University Hospital during 2011–2013 were recruited (N = 467 at baseline). The participants were followed after 4 years and 6 years. MetS was assessed at baseline. Successful aging was evaluated at baseline, 4-year follow-up, and 6-year follow-up. We adopted an extended definition of successful aging, which was defined as three major domains: physiological, psychological, and sociological and economic domains. Generalized linear mixed models were used to assess the association between MetS and successful aging adjusting for time (follow-up years), age, sex, years of education, alcohol consumption and MetS×time interaction term. The mean age of the study population was 72.9 (SD 5.5) years. The absence of baseline MetS had a positive effect on the probability of successful aging over six years. The absences of abdominal obesity, hyperglycemia, reduced high-density lipoprotein cholesterol, and hypertension were associated with the physiological successful aging. The absence of hypertension was the most significant predictor of physiological successful aging [aOR (95% CI) = 2.76 (1.67–4.58), pPtrend <0.001). We found that MetS is a risk factor of successful aging among community-dwelling older adults. Public health policy should aim at avoidance of MetS in order to facilitate successful aging in older population.Funding Information
- Ministry of Science and Technology, Taiwan (100-2314-B-002-103, 101-2314-B-002-126-MY3, 103-2314-B-002-033-MY3, 104-2314-B-002-038-MY3, and 107-2314-B-002-186-MY3)
This publication has 52 references indexed in Scilit:
- Metabolic syndrome and functional ability in older age: The InCHIANTI studyClinical Nutrition, 2014
- Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional studyBMJ Open, 2013
- Bidirectional Association Between Depression and Metabolic SyndromeDiabetes Care, 2012
- Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation in community-dwelling older personsAge and Ageing, 2009
- Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged AdultsDiabetes Care, 2009
- Can Successful Aging and Chronic Illness Coexist in the Same Individual? A Multidimensional Concept of Successful AgingJournal of the American Medical Directors Association, 2009
- Metabolic Syndrome and Physical Decline in Older Persons: Results from the Health, Aging and Body Composition StudyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Metabolic Syndrome and Dementia Risk in a Multiethnic Elderly CohortDementia and Geriatric Cognitive Disorders, 2007
- Successful AgingThe Gerontologist, 1997
- Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily LivingThe Gerontologist, 1969