Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota
Open Access
- 18 December 2019
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2019, 1-8
- https://doi.org/10.1155/2019/8496817
Abstract
Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota: Niuhuang Jiedu tablet (NJT), a realgar (As2S2) containing Traditional Chinese Medicine (TCM), is a well-known formula. The safety of NJT is of growing concern since arsenic (As) is considered as one of the most toxic elements. NJT was demonstrated to be safer than realgar by our previous experiments and some other studies. The toxicity of realgar has been shown to be related to the amount of soluble or bioaccessible arsenic. In this study, the influences of the other TCMs in NJT on the bioaccessibility of arsenic from realgar, and the roles of gut microbiota during this process were investigated in vitro. Results showed that Dahuang (Rhei Radix et Rhizoma), Huangqin (Scutellariae Radix), Jiegeng (Platycodonis Radix), and Gancao (Glycyrrhizae Radix et Rhizoma) could significantly reduce the bioaccessibility of arsenic from realgar in artificial gastrointestinal fluids. Gut microbiota played an important role in decreasing the bioaccessibility of realgar because it was demonstrated to be able to absorb the soluble arsenic from realgar in the incubation medium. Dahuang, Huangqin, and Jiegeng could modulate the gut microbiota to enhance its arsenic absorption activity.Keywords
Funding Information
- National Natural Science Foundation of China (81803715, BJ-2016-039)
This publication has 41 references indexed in Scilit:
- Preabsorptive Metabolism of Sodium Arsenate by Anaerobic Microbiota of Mouse Cecum Forms a Variety of Methylated and Thiolated ArsenicalsChemical Research in Toxicology, 2011
- As 4 S 4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemiaProceedings of the National Academy of Sciences of the United States of America, 2010
- Arsenic Metabolism by Human Gut Microbiota upon in Vitro Digestion of Contaminated SoilsEnvironmental Health Perspectives, 2010
- A human gut microbial gene catalogue established by metagenomic sequencingNature, 2010
- Traditional Chinese medicine: balancing the gut ecosystemPhytotherapy Research, 2009
- In vitro biotransformation of dimethylarsinic acid and trimethylarsine oxide by anaerobic microflora of mouse cecum analyzed by HPLC-ICP-MS and HPLC-ESI-MSJournal of Analytical Atomic Spectrometry, 2009
- Metabolic profiling studies on the toxicological effects of realgar in rats by 1H NMR spectroscopyToxicology and Applied Pharmacology, 2009
- Mineral Arsenicals in Traditional Medicines: Orpiment, Realgar, and ArsenoliteThe Journal of pharmacology and experimental therapeutics, 2008
- Analysis and leaching characteristics of mercury and arsenic in Chinese medicinal materialAnalytica Chimica Acta, 2002
- RELEASE OF SOLUBLE ARSENIC FROM REALGAR IN SIMULATED GASTRIC JUICEAnalytical Letters, 2001