Background: Extracts of Curcuma longa rhizome extracts were investigated for their biological activity. Methodology: The presence of phytochemicals and antitrypanosomal activities were investigated. Results: The extracts contained the phytochemicals (Alkaloid, Anthraquinone, Carbohydrates, Cardiac Glycosides, Flavonoid, Glyco-sides, Phenols, Saponin, Steroid, Tannin and Triterpenes) in table 1 and 2. The extracts showed very good activity against the parasite from figure 1, 2 and 3. Discussion: The presence of the phytochemical confirms their medicinal potentials. The crude extracts of Curcuma longa were analyzed in vitro for trypanocide activity on Trypanosoma brucei brucei at concentration 100.0 mg/ml, 50.0 mg/ml, 25 mg/ml, 12.5 mg/ml and 6.25 mg/ml. The best activity was seen in Petroleum ether extract, followed by the ethanol extract, then Chloroform which was still impressive. Conclusion: The results obtained from this study show that the turmeric contains potential antimicrobial components which will be of great use for the advancement of remedies by pharmaceutical industries as a therapy against various diseases.