CLINICAL EFFICACY OF PHOSPHOLIPID-CONTAINING PREPARATIONS OF DIFFERENT ORIGIN UNDER EXPERIMENTAL GASTROENTEROPATHOLOGY IN MICE

Abstract

Diseases of the digestive system are extremely common among animals, especially young animals. The purpose of this work was to determine the features of the corrective effectiveness of reparative agents based on phospholipids of various origins based on the results of a comprehensive study of clinical, hematological, immunological parameters and the structural and functional state of immunocompetent organs in CBA mice with experimental gastroenteropathology.As a result of the reproduction of an acute form of hemorrhagic gastroenteritis with diarrheal syndrome in CBA mice, the development of characteristic clinical symptoms was noted. Regardless of the nature of the origin of phospholipids, preparations based on them exhibited a pronounced reparative effect on cell damage. At the same time, the effectiveness of the dietary supplement "FLP-MD" based on phospholipids from milk according to some indicators turned out to be better than the preparation Essentiale-forte based on phospholipids from soybeans. Thus, the peculiarity of the effect of the dietary supplement "FLP-MD" on the organism of sick mice is the acceleration of the restoration of the general clinical state of the animals (on the 8-10th day from the beginning of the introduction of the dietary supplement into the body versus the 10-12th day when using the drug essentiale-forte), restoration of the mass of lymphoid organs (thymus and spleen); an increase in the relative number of T-lymphocytes in the blood by 1.4 times due to the activation of proliferative processes in the organs of the immune system (4.8 times in the spleen, 1.5 times in the thymus).