The European Commission had the same mandate for all the individual negotiations and thus little to no variance can be attributed to the EU's official position and approach to the individual Economic Partnership Agreement (EPA) negotiations. This chapter reviews that negotiation processes are formed by domestic and regional dynamics in the individual EPA configurations which differ both from a traditional international-domestic relationship scenario of multilateral trade negotiations as well as from a traditional north-south negotiation scenario. It develops a theoretical account of the changing patterns in north-south trade negotiations and maps actors' alliances in the Southern African Development Community (SADC) EPA group and the role of the Republic of South Africa as the regional hegemon. The chapter focuses on the East African Community (EAC) EPA negotiations and the role of Kenya and explains with a comparison of the two case studies and discusses the prospect of a new type of north-south relations.