Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis
Open Access
- 31 December 2021
- journal article
- research article
- Published by Turk Noroloji Dernegi in Türk Nöroloi Dergisi
- Vol. 27 (4), 390-393
- https://doi.org/10.4274/tnd.2021.70962
Abstract
Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers. Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group. Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS.Keywords
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