A new corrosion-inhibiting strategy for biodegradable magnesium: reduced nicotinamide adenine dinucleotide (NADH)
Open Access
- 10 December 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 8 (1), 17743
- https://doi.org/10.1038/s41598-018-36240-3
Abstract
Utilization of biodegradable metals in biomedical fields is emerging because it avoids high-risk and uneconomic secondary surgeries for removing implantable devices. Mg and its alloys are considered optimum materials for biodegradable implantable devices because of their high biocompatibility; however, their excessive and uncontrollable biodegradation is a difficult challenge to overcome. Here, we present a novel method of inhibiting Mg biodegradation by utilizing reduced nicotinamide adenine dinucleotide (NADH), an endogenous cofactor present in all living cells. Incorporating NADH significantly increases Mg corrosion resistance by promoting the formation of thick and dense protective layers. The unique mechanism by which NADH enables corrosion inhibition was discovered by combined microscopic and spectroscopic analyses. NADH is initially self-adsorbed onto the surface of Mg oxide layers, preventing Cl− ions from dissolving Mg oxides, and later recruits Ca2+ ions to form stable Ca-P protective layers. Furthermore, stability of NADH as a corrosion inhibitor of Mg under physiological conditions were confirmed using cell tests. Moreover, excellent cell adhesion and viability to Mg treated with NADH shows the feasibility of introduction of NADH to Mg-based implantable system. Our strategy using NADH suggests an interesting new way of delaying the degradation of Mg and demonstrates potential roles for biomolecules in the engineering the biodegradability of metals.This publication has 44 references indexed in Scilit:
- Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phasesScientific Reports, 2013
- Ductile Biodegradable Mg‐Based Metallic Glasses with Excellent BiocompatibilityAdvanced Functional Materials, 2013
- Polylactic acid coating on a biodegradable magnesium alloy: An in vitro degradation study by electrochemical impedance spectroscopyThin Solid Films, 2012
- Determining the Extremes of the Cellular NAD(H) Level by Using an Escherichia coli NAD + -Auxotrophic MutantApplied and Environmental Microbiology, 2011
- The effects of surface and biomolecules on magnesium degradation and mesenchymal stem cell adhesionJournal of Biomedical Materials Research Part A, 2011
- Biodegradable Metals for Cardiovascular Stent Application: Interests and New OpportunitiesInternational Journal of Molecular Sciences, 2011
- A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implantsBiomaterials, 2010
- Revolutionizing biodegradable metalsMaterials Today, 2009
- Electrosprayed Enzyme Coatings as Bioinspired Alternatives to Bioceramic Coatings for Orthopedic and Oral ImplantsAdvanced Functional Materials, 2009
- In vivo corrosion of four magnesium alloys and the associated bone responseBiomaterials, 2005