Infectivity of deceased COVID-19 patients
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Open Access
- 5 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in International journal of legal medicine
- Vol. 135 (5), 2055-2060
- https://doi.org/10.1007/s00414-021-02546-7
Abstract
The duration of infectivity of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in living patients has been demarcated. In contrast, a possible SARS-CoV-2 infectivity of corpses and subsequently its duration under post mortem circumstances remain to be elucidated. The aim of this study was to investigate the infectivity and its duration of deceased COVID-19 (coronavirus disease) patients. Four SARS-CoV-2 infected deceased patients were subjected to medicolegal autopsy. Post mortem intervals (PMI) of 1, 4, 9 and 17 days, respectively, were documented. During autopsy, swabs and organ samples were taken and examined by RT-qPCR (real-time reverse transcription-polymerase chain reaction) for the detection of SARS-CoV-2 ribonucleic acid (RNA). Determination of infectivity was performed by means of virus isolation in cell culture. In two cases, virus isolation was successful for swabs and tissue samples of the respiratory tract (PMI 4 and 17 days). The two infectious cases showed a shorter duration of COVID-19 until death than the two non-infectious cases (2 and 11 days, respectively, compared to > 19 days), which correlates with studies of living patients, in which infectivity could be narrowed to about 6 days before to 12 days after symptom onset. Most notably, infectivity was still present in one of the COVID-19 corpses after a post-mortem interval of 17 days and despite already visible signs of decomposition. To prevent SARS-CoV-2 infections in all professional groups involved in the handling and examination of COVID-19 corpses, adequate personal safety standards (reducing or avoiding aerosol formation and wearing FFP3 [filtering face piece class 3] masks) have to be enforced for routine procedures.Keywords
Funding Information
- Johann Wolfgang Goethe-Universität, Frankfurt am Main
This publication has 17 references indexed in Scilit:
- Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing FacilityThe New England Journal of Medicine, 2020
- Corrigendum to “COVID-19 in forensic medicine unit personnel: Observation from Thailand” [J Forensic Legal Med 72 May 2020, 101964]Journal of Forensic and Legal Medicine, 2020
- Endothelial cell infection and endotheliitis in COVID-19The Lancet, 2020
- COVID-19 in forensic medicine unit personnel: Observation from ThailandJournal of Forensic and Legal Medicine, 2020
- Virological assessment of hospitalized patients with COVID-2019Nature, 2020
- COVID-19 may transmit through aerosolIrish Journal of Medical Science, 2020
- Autopsy in suspected COVID-19 casesJournal of Clinical Pathology, 2020
- Neural RRT*: Learning-Based Optimal Path PlanningIEEE Transactions on Automation Science and Engineering, 2020
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challengesInternational Journal of Antimicrobial Agents, 2020
- The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitorProceedings of the National Academy of Sciences of the United States of America, 2003