Long-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function
Open Access
- 20 September 2021
- journal article
- review article
- Published by Frontiers Media SA in American Journal of Translational Research
Abstract
Adolescence is a period of incredible change, especially within the brain's reward circuitry. Stress, including social isolation, during this time has profound effects on behaviors associated with reward and other neuropsychiatric disorders. Because the Nucleus Accumbens (NAc), is crucial to the integration of rewarding stimuli, the NAc is especially sensitive to disruptions by adolescent social isolation stress. This review highlights the long-term behavioral consequences of adolescent social isolation rearing on the NAc. It will discuss the cellular and molecular changes within the NAc that might underlie the long-term effects on behavior. When available sex-specific effects are discussed. Finally by mining publicly available data we identify, for the first time, key transcriptional profiles induced by adolescence social isolation in genes associated with dopamine receptor 1 and 2 medium spiny neurons and genes associated with cocaine self-administration. Together, this review provides a comprehensive discussion of the wide-ranging long-term impacts of adolescent social isolation on the dopaminergic system from molecules through behavior.Keywords
Funding Information
- National Institute on Drug Abuse
This publication has 130 references indexed in Scilit:
- Neurobiology of the Adolescent Brain and Behavior: Implications for Substance Use DisordersJournal of the American Academy of Child & Adolescent Psychiatry, 2010
- Effect of environmental enrichment on escalation of cocaine self-administration in ratsPsychopharmacology, 2010
- Early Adolescent Depressive Symptoms: Prediction from Clique Isolation, Loneliness, and Perceived Social AcceptanceJournal of Abnormal Child Psychology, 2010
- Social and physical environment alter cocaine conditioned place preference and dopaminergic markers in adolescent male ratsNeuroscience, 2009
- The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortexBehavioural Brain Research, 2009
- Back to the future: The organizational–activational hypothesis adapted to puberty and adolescenceHormones and Behavior, 2009
- Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intakePharmacology & Therapeutics, 2008
- Striatal Plasticity and Basal Ganglia Circuit FunctionNeuron, 2008
- Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in ratsNeuroscience, 2008
- Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey ReplicationArchives of General Psychiatry, 2005