The interaction of nicotine concentration and device power on electronic nicotine delivery system (ENDS) abuse liability among exclusive ENDS users and dual users of ENDS and combustible cigarettes.
- 1 December 2022
- journal article
- research article
- Published by American Psychological Association (APA) in Experimental and Clinical Psychopharmacology
- Vol. 30 (6), 973-982
- https://doi.org/10.1037/pha0000523
Abstract
Public Health Significance Several countries have current policy in place or are considering limiting the nicotine concentration found in the liquid solution of electronic nicotine delivery systems (ENDS) to decrease their abuse liability. This study suggests that limiting liquid nicotine concentration without regulating ENDS device power may be insufficient as abuse liability for low nicotine ENDS increases if paired with greater device power. Open-system electronic nicotine delivery systems (ENDS) permit modifications to device characteristics such as power, potentially increasing nicotine and toxicant delivery. Limiting liquid nicotine concentration may carry unintended consequences by prompting users to increase device power to increase nicotine delivery. This study examined the abuse liability of ENDS across nicotine concentration and power settings. In a clinical laboratory study, n = 19 exclusive ENDS users and n = 13 dual ENDS/cigarette users, aged 21-55 completed four Latin-square ordered conditions that varied by liquid nicotine concentration (10 mg/ml [low], 30 mg/ml [high]) and device power (15 watts [low], 30 watts [high]), that were followed by a fifth own brand (OB) condition. A progressive ratio task (PRT) using bar presses to earn ENDS puffs was used to assess abuse liability and compare between conditions using mixed effects linear regressions. The low nicotine/high watt condition was associated with a significantly higher number of bar presses and puffs earned relative to the OB ENDS, high nicotine/high watt, and high nicotine/low watt conditions (p < .05). Findings appeared to be driven largely by exclusive ENDS users; most comparisons were not significant among dual users. Participants worked significantly harder for puffs of low nicotine/high watt ENDS, highlighting previous findings that suggest limiting liquid nicotine concentration without addressing power settings may be insufficient to reduce the abuse liability of ENDS.Funding Information
- National Institutes of Health
- Food and Drug Administration (U54DA036105)
This publication has 46 references indexed in Scilit:
- Nicotine AddictionThe New England Journal of Medicine, 2010
- Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humansJournal of Psychopharmacology, 2004
- Sex differences in the subjective and reinforcing effects of cigarette nicotine dosePsychopharmacology, 2002
- The Synergistic Effects of Combining Cocaine and Heroin (“Speedball”) Using a Progressive-Ratio Schedule of Drug ReinforcementPharmacology Biochemistry and Behavior, 1998
- Tobacco abstinence, smoking cues, and the reinforcing value of smokingPharmacology Biochemistry and Behavior, 1994
- REINFORCING EFFECTS OF CAFFEINE IN COFFEE AND CAPSULESJournal of the Experimental Analysis of Behavior, 1989
- Evaluation of a low to middle tar/medium nicotine cigarette designed to maintain nicotine delivery to the smokerPsychopharmacology, 1988
- Signs and Symptoms of Tobacco WithdrawalArchives of General Psychiatry, 1986
- Comparison of progressive-ratio performance maintained by cocaine, methylphenidate and secobarbitalPsychopharmacology, 1975
- Progressive Ratio as a Measure of Reward StrengthScience, 1961