Background: Omentin-1 is a novel adipocytokine expressed from visceral adipose tissues and is closely associated with obesity, inflammation and coronary artery disease. Central or abdominal obesity has a dynamic role in the development of coronary heart disease by enviably effecting conventional risk factors. Waist circumference is a sensitive, reliable and specific anthropometrical indicator of central obesity. Thus, the present study aimed to evaluate the correlation between central obesity measured by waist circumference and plasma omentin-1 in patients with coronary heart disease. Methods: The study was performed in cardiac unit of Civil Hospital Karachi and Karachi Institute of Heart Diseases (KIHD), Pakistan from January 2016-August 2016. A total of 250 patients (92 females, 158 males) with coronary artery disease were evaluated. Waist circumference was measured at the level of umbilicus. Determination of Omentin-1 was done by an enzyme-linked immunosorbent assay (ELISA). Data was evaluated by SPSS and one way ANOVA was performed to determine the baseline characteristics of study population. Pearson’s correlation was used for association between waist circumference and plasma omentin-1. Results: There was a negative association between waist circumference and plasma omentin-1 (R = -0.68, p < 0.01) in males and (R= – 0.50, p < 0.01) in female patients of coronary heart disease. Waist circumference was found an independent determinant of circulating omentin-1 while performing multivariate logistic regression analysis, after adjusting cardio-metabolic risk factors like age, body mass index, lipid profile, blood sugar levels and smoking. Conclusion: There was a negative correlation of plasma omentin-1 and central obesity in coronary heart disease. Keywords: Central Obesity; Coronary Heart Disease; Omentin-1; Waist Circumference.