Introduction: Breast cancer is the most prevalent cancer among women population. Pain during and after chemotherapy is of various types and has no background information on the mechanism and treatment. Aim: To analyse pain after chemotherapy in breast cancer patients. Materials and Methods: It was a Prospective Observational Cohort of 6 month time period at Omega Hospitals, Guntur with 76 patients. Data was collected by direct interaction either with the patient or the patient representative or by studying patient’s profile through questionnaire. Statistical Analysis: All the collected data was entered into Excel sheet (Microsoft Excel 2016 MSO (16.0.13328.20262) 32-bit: Windows 11 version). The collected data was transported to SPSS (version – 28) for analysis. Results: The intermittent pain was seen in most of the patients (40.8%) along with Continuous Pain (14.5%) & Predominantly Neuropathic Pain (3.9%). Conclusion: Inspite of robustic research on the characteristics of pain, patients complain of pain in other locations too. Also, researches should throw light on management, prevention and identification of pain by various techniques like radiation or surgery. We can certainly hope that by considering diagnosis, management, prevention we can improve clinical patient outcome with less adverse drug reactions.