Genetic Factors as the Basis of Sex Differences in Damage to Lung Endothelium and Regulation of Angiogenesis Cells in Modeling Pulmonary Emphysema in C57BL/6 Mice with Dyslipidemia and Hyperglycemia
- 16 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bulletin of Experimental Biology and Medicine
- Vol. 170 (3), 326-331
- https://doi.org/10.1007/s10517-021-05061-2
Abstract
We studied the formation of injuries in lung endothelium and the response of angiogenesis cells during modeling of pulmonary emphysema in male and female C57BL/6 mice with metabolic disorders. Hemodynamic disturbances and reduction in the area of the microvasculature caused by combined pathology in male mice were more pronounced than in females. Mobilization and migration of angiogenic precursors were impaired in both male and female mice. In males, activity of recruiting endothelial progenitor cells, vascular smooth muscle cells, luminal cells of nascent vessels and pericytes into the lungs was additionally reduced. In females, accumulation of endothelial progenitor cells (CD45—CD31+CD34+), vascular smooth muscle cells, and pericytes in the lungs was observed, which indicated activation of endothelial regeneration. Sex differences in the reaction of the lung endothelium and angiogenesis cells can be explained by genetic factors of lipid and glucose metabolism.Keywords
This publication has 12 references indexed in Scilit:
- Endothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary DiseaseInternational Journal of Molecular Sciences, 2019
- Role of β Cell Precursors in the Regeneration of Insulin-Producing Pancreatic β Cells under the Influence of Glucagon-Like Peptide 1Bulletin of Experimental Biology and Medicine, 2018
- Epidemiology of Gender Differences in Diabetes and ObesityPublished by Springer Science and Business Media LLC ,2017
- Cellular Mechanisms Driving Sex Differences in Adipose Tissue Biology and Body Shape in Humans and Mouse ModelsPublished by Springer Science and Business Media LLC ,2017
- Genetic Basis for Sex Differences in Obesity and Lipid MetabolismAnnual Review of Nutrition, 2017
- Benefits of l-alanine or l-arginine supplementation against adiposity and glucose intolerance in monosodium glutamate-induced obesityEuropean Journal of Nutrition, 2016
- Scale dependence of structure-function relationship in the emphysematous mouse lungFrontiers in Physiology, 2015
- Effects of inflammation on stem cells: together they strive?EMBO Reports, 2015
- Short-Term Cigarette Smoke Exposure Leads to Metabolic Alterations in Lung Alveolar CellsAmerican Journal of Respiratory Cell and Molecular Biology, 2014
- Metabolic syndrome: from epidemiology to systems biologyNature Reviews Genetics, 2008