Seaweed-Derived Sulfated Polysaccharides as Potential Agents for Prevention and Treatment of Influenza and COVID-19
- 21 October 2021
- journal article
- Published by Publishing House OKI in Antibiotics and Chemotherapy
- Vol. 66 (7-8), 50-66
- https://doi.org/10.37489/0235-2990-2021-66-7-8-50-66
Abstract
The review presents materials describing the seaweed-derived sulfated polysaccharides (SPS) as potential means for prevention and treatment of viral diseases of the respiratory tract, mainly influenza and COVID-19. The literature materials on the pathogenetic targets of influenza viruses and SARS-CoV-2, on the antiviral potential of SPS derived from red, brown and green algae, as well as on the mechanisms of antiviral action of these unique compounds are summarized. Seaweed SPS are characterized by high antiviral activity, good solubility, and almost complete absence of toxicity. Pathogens of respiratory infections do not form resistance under the SPS influence. The abovementioned facts allow us to consider these compounds as promising candidates for the creation of medicines, dietary supplements, and functional food products with antiviral and, above all, anti-influenza and anti-coronavirus activity on their basis in the future.Keywords
This publication has 91 references indexed in Scilit:
- Efficacy of a Carrageenan nasal spray in patients with common cold: a randomized controlled trialRespiratory Research, 2013
- Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common coldBMC Complementary and Alternative Medicine, 2012
- Preparation and anti-influenza A virus activity of κ-carrageenan oligosaccharide and its sulphated derivativesFood Chemistry, 2012
- Structural Characteristics and Biological Activity of Fucoidans from the Brown Algae Alaria sp. and Saccharina japonica of Different Reproductive StatusChemistry & Biodiversity, 2012
- Iota-Carrageenan Is a Potent Inhibitor of Influenza A Virus InfectionPLOS ONE, 2010
- Evolution of Highly Pathogenic Avian Influenza H5N1 Virus in Natural Ecosystems of Northern Eurasia (2005–08)Avian Diseases, 2010
- Peyer's Patches: The Immune Sensors of the IntestineInternational Journal of Inflammation, 2010
- Iota-Carrageenan is a potent inhibitor of rhinovirus infectionVirology Journal, 2008
- Here a virus, there a virus, everywhere the same virus?Trends in Microbiology, 2005
- Preparation of low-molecular weight alginic acid by acid hydrolysisCarbohydrate Polymers, 2000