This study aims to study and compare stress level during the COVID-19 situation of undergraduate students with different gender and year levels. The sample were 276 undergraduate students in the 2nd semester of the academic year 2020, being selected by voluntary sampling. The tool was the stress level in the situation of the Coronavirus disease 2019 measurement form with online system Google from. The frequency, percentage, mean, standard deviation, including hypothesis testing using One-Way ANOVA were analyzed as the statistics. The finding showed that: 1) Undergraduate students’ stress level during the COVID-19 situation, almost of 118 students was a high level of stress, representing 42.75%, followed by severe level of stress, 107 students, representing 38.77%. The moderate level of stress was 45 students, representing 16.30%, and the low level of stress was 6 students, representing for 2.17%. 2) There was statistically significant different of stress level during the COVID-19 situation of students with different gender (p < .05). Female students’ stress level was higher than male students. There was no different of stress level during the COVID-19 situation of students with different year levels.