Membrane Exporters of Fluoride Ion
- 20 June 2021
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 90 (1), 559-579
- https://doi.org/10.1146/annurev-biochem-071520-112507
Abstract
Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F-), a common xenobiotic in natural environments that causes broad-spectrum harm to metabolic pathways. This review focuses on advances in the last ten years toward understanding the microbial response to cytoplasmic accumulation of F-, with a special emphasis on the structure and mechanisms of the proteins that microbes use to export fluoride: the CLCF family of F-/H+ antiporters and the Fluc/FEX family of F- channels.Keywords
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