Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review
Open Access
- 23 August 2019
- Vol. 55 (9), 522
- https://doi.org/10.3390/medicina55090522
Abstract
Kidneys have an important role in regulating water volume, blood pressure, secretion of hormones and acid-base and electrolyte balance. Kidney dysfunction derived from acute injury can, under certain conditions, progress to chronic kidney disease. In the late stages of kidney disease, treatment is limited to replacement therapy: Dialysis and transplantation. After renal transplant, grafts suffer from activation of immune cells and generation of oxidant molecules. Anesthetic preconditioning has emerged as a promising strategy to ameliorate ischemia reperfusion injury. This review compiles some significant aspects of renal physiology and discusses current understanding of the effects of anesthetic preconditioning upon renal function and ischemia reperfusion injury, focusing on opioids and its properties ameliorating renal injury. According to the available evidence, opioid preconditioning appears to reduce inflammation and reactive oxygen species generation after ischemia reperfusion. Therefore, opioid preconditioning represents a promising strategy to reduce renal ischemia reperfusion injury and, its application on current clinical practice could be beneficial in events such as acute renal injury and kidney transplantation.Keywords
This publication has 136 references indexed in Scilit:
- Effects of propofol on renal ischemia/reperfusion injury in ratsExperimental and Therapeutic Medicine, 2013
- Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activationJournal of Translational Medicine, 2013
- Morphine Induces Albuminuria by Compromising Podocyte IntegrityPLOS ONE, 2013
- Combined Preconditioning and Postconditioning Provides Synergistic Protection against Liver Ischemic Reperfusion InjuryInternational Journal of Biological Sciences, 2012
- Endothelin and the Renal VasculatureContributions to nephrology, 2011
- Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Nondiabetic Patients Undergoing Coronary Artery Bypass Graft Surgery: A Secondary Analysis of 2 Small Randomized TrialsAmerican Journal of Kidney Diseases, 2010
- Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injuryKidney International, 2009
- Inflammation in Acute Kidney InjuryNephron Experimental Nephrology, 2008
- TLR4 activation mediates kidney ischemia/reperfusion injuryJCI Insight, 2007
- Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injuryCritical Care, 2007