Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
Open Access
- 5 January 2021
- Vol. 8 (1), 1
- https://doi.org/10.3390/medicines8010001
Abstract
Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development.Keywords
This publication has 64 references indexed in Scilit:
- Helicobacter pylori infection and atrophic gastritisAfrican Health Sciences, 2013
- Race, African Ancestry, and Helicobacter pylori Infection in a Low-Income United States PopulationCancer Epidemiology, Biomarkers & Prevention, 2011
- Molecular cross-talk between Helicobacter pylori and human gastric mucosaWorld Journal of Gastroenterology, 2011
- Helicobacter pylori vacuolating toxin A and apoptosisCell Communication and Signaling, 2011
- Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease RiskClinical Microbiology Reviews, 2010
- Helicobacter pylori: gastric cancer and beyondNature Reviews Cancer, 2010
- The enigma of Helicobacter pylori infection and gastric cancerIndian Journal of Gastroenterology, 2010
- Helicobacter pylori: a poor man's gut pathogen?Gut Pathogens, 2010
- CagA-producing Helicobacter pylori and increased risk of gastric cancer: a nested case–control study in KoreaBritish Journal of Cancer, 2006
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986