Improving Diabetic Foot Ulcer Healing with Adjuvant Bitter Melon Leaf Extract (Momordica charantia L.)
Open Access
- 3 January 2022
- journal article
- Published by Scientific Foundation SPIROSKI in Open Access Macedonian Journal of Medical Sciences
- Vol. 10 (T8), 122-126
- https://doi.org/10.3889/oamjms.2022.9503
Abstract
BACKGROUND: Diabetes mellitus is a serious disease that affects more than 340 million people and causes approximately 20% of diabetic ulcer cases worldwide. Wound healing is a complex and dynamic process in restoring cellular structures and tissue layers. It consists of four continuous overlapping phases that are precisely programmed AIM: This study aims to examine the adjuvant administration of bitter melon leaf extract to increase the healing of diabetic foot ulcers (DFU). METHODS: This study used a randomized, double-blind, and placebo-controlled trial. A total of 30 DFU patients with a perfusion, extent, depth, infection, and sensation (PEDIS) score of 1–8 who met the criteria were divided into two groups, namely, the treatment group with adjuvant administration of bitter melon leaf extract at a dose of 6 g/day as many as 15 patients and the control group 15 patients with placebo. This intervention was carried out for 4 weeks. DFU cure was measured by PEDIS scores at baseline, weeks 2, 3, and the end of week 4. Data were analyzed using paired t-test and independent t-test. RESULTS: After 4 weeks of treatment, the PEDIS score in the treatment group decreased at week 2 (0.9 ± 1.8), but not significant (p = 0.19), decreased at week 3 (1.9 ± 1.9) and significant (p = 0.01), decreased in week IV (2.3 ± 2.1) and significantly (p = 0.001). The control group experienced a decrease in week 2 (0.3 ± 2.3), but not significant (p = 0.71), decreased in week 3 (1.2 ± 2.5), but not significant (p = 0.18), decreased in week 4 (1.9 ± 2.7) and significantly (p = 0.03), and there was an effect of adjuvant administration of bitter melon leaf extract on the cure of DFU (p = 0.004).Keywords
This publication has 25 references indexed in Scilit:
- Erratum Regarding “US Renal Data System 2014 Annual Data Report: Epidemiology of Kidney Disease in the United States” (Am J Kidney Dis. 2015;66[1][suppl 1]:S1-S305)American Journal of Kidney Diseases, 2015
- Pectic polysaccharide from the green fruits of Momordica charantia (Karela): structural characterization and study of immunoenhancing and antioxidant propertiesCarbohydrate Research, 2014
- Momordica charantia ointment accelerates diabetic wound healing and enhances transforming growth factor-β expressionJournal of Wound Care, 2014
- A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica speciesFood Science and Human Wellness, 2014
- The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skinJournal of Dermatological Treatment, 2012
- Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studiesThe Lancet, 2010
- The effect of topical extract ofMomordica charantia(bitter gourd) on wound healing in nondiabetic rats and in rats with diabetes induced by streptozotocinClinical and Experimental Dermatology, 2009
- Wound-Healing Property ofMomordica charantiaL. Fruit PowderJournal of Herbal Pharmacotherapy, 2006
- Pharmacological actions and potential uses of Momordica charantia: a reviewJournal of Ethnopharmacology, 2004
- Vascular Endothelial Growth Factor: A Novel Endocrine Defensive Response to HypoglycemiaJournal of Clinical Endocrinology & Metabolism, 2002