A Pyrene‐Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals

Abstract

We herein report a circularly polarized luminescent (CPL) probe that can respond to chirality of nucleic acids. An achiral nanostructure was prepared by hybridization of symmetric serinol nucleic acid (SNA) containing pyrene-modified residues. When chiral oligomers were added that were complementary to the SNA, they induced helicity into the SNA nanowire. Efficient circular dichroism (CD) signal amplification was observed when pyrene was attached to uracil base through a rigid alkynyl linker. Both CPL signals and CD signals were observed that depended on the chirality of added acyclic threoninol nucleic acid ( a TNA) oligomer. This system can be used to convert chirality of chiral biomolecules into chiroptical signals.