Recent advances in the role of supramolecular hydrogels in drug delivery
- 30 December 2014
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Drug Delivery
- Vol. 12 (7), 1149-1161
- https://doi.org/10.1517/17425247.2015.997707
Abstract
Introduction: Supramolecular hydrogels, formed by noncovalent crosslinking of polymeric chains in water, constitute an interesting class of materials that can be developed specifically for drug delivery and biomedical applications. The biocompatibility, stimuli responsiveness to various external factors, and powerful functionalization capacity of these polymeric networks make them attractive candidates for novel advanced dosage form design. Areas covered: This review summarizes the significance of supramolecular hydrogels in various biomedical and drug delivery applications. The recent advancement of these hydrogels as potential advanced drug delivery systems (for gene, protein, anticancer and other drugs) is discussed. The importance of these hydrogels in biomedical applications, particularly in tissue engineering, biosensing, cell-culture research and wound treatment is briefly described. Expert opinion: The use of supramolecular hydrogels in drug delivery is still in very early stages. However, the potential of such a system is undeniably important and very promising. A number of recent studies have been conducted, which mainly focus on the use of cyclodextrin-based host-guest complex as well as other supramolecular motifs to form supramolecular hydrogels for delivery of various classes of drugs, therapeutic agents, proteins and genes. However, there are still plenty of opportunities for further development in this area for drug delivery and other biomedical applications.Keywords
This publication has 82 references indexed in Scilit:
- Supramolecular Anchoring of DNA Polyplexes in Cyclodextrin-Based Polypseudorotaxane Hydrogels for Sustained Gene DeliveryBiomacromolecules, 2012
- Development and in-vivo characterization of supramolecular hydrogels for intrarenal drug deliveryBiomaterials, 2012
- Electrochemical Immunosensors for Detection of Cancer Protein BiomarkersACS Nano, 2012
- In Situ Supramolecular Assembly and Modular Modification of Hyaluronic Acid Hydrogels for 3D Cellular EngineeringACS Nano, 2012
- Cucurbit[8]uril Mediated Donor–Acceptor Ternary Complexes: A Model System for Studying Charge-Transfer InteractionsThe Journal of Physical Chemistry B, 2012
- Fabrication of pH-sensitive graphene oxide–drug supramolecular hydrogels as controlled release systemsJournal of Materials Chemistry, 2012
- Physical chemistry of supramolecular polymer networksChemical Society Reviews, 2011
- Synthesis of a biocleavable polyrotaxane-plasmid DNA (pDNA) polyplex and its use for the rapid nonviral delivery of pDNA to cell nucleiNature Protocols, 2006
- Hydrogels for biomedical applicationsAdvanced Drug Delivery Reviews, 2001
- Synthesis and characterization of biodegradable polyrotaxane as a novel supramolecular-structured drug carrierJournal of Biomaterials Science, Polymer Edition, 1997