Preliminary Observations of Resting-State Magnetoencephalography in Nonmedicated Children with Obsessive-Compulsive Disorder
- 1 December 2022
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Child and Adolescent Psychopharmacology
- Vol. 32 (10), 522-532
- https://doi.org/10.1089/cap.2022.0036
Abstract
Background: Cortico-striato-thalamo-cortical (CSTC) network alterations are hypothesized to contribute to symptoms of obsessive-compulsive disorder (OCD). To date, very few studies have examined whether CSTC network alterations are present in children with OCD, who are medication naive. Medication-naive pediatric imaging samples may be optimal to study neural correlates of illness and identify brain-based markers, given the proximity to illness onset. Methods: Magnetoencephalography (MEG) data were analyzed at rest, in 18 medication-naive children with OCD (M = 12.1 years ±2.0 standard deviation [SD]; 10 M/8 F) and 13 typically developing children (M = 12.3 years ±2.2 SD; 6 M/7 F). Whole-brain MEG-derived resting-state functional connectivity (rs-fc), for alpha- and gamma-band frequencies were compared between OCD and typically developing (control) groups. Results: Increased MEG-derived rs-fc across alpha- and gamma-band frequencies was found in the OCD group compared to the control group. Increased MEG-derived rs-fc at alpha-band frequencies was evident across a number of regions within the CSTC circuitry and beyond, including the cerebellum and limbic regions. Increased MEG-derived rs-fc at gamma-band frequencies was restricted to the frontal and temporal cortices. Conclusions: This MEG study provides preliminary evidence of altered alpha and gamma networks, at rest, in medication-naive children with OCD. These results support prior findings pointing to the relevance of CSTC circuitry in pediatric OCD and further support accumulating evidence of altered connectivity between regions that extend beyond this network, including the cerebellum and limbic regions. Given the substantial portion of children and youth whose OCD symptoms do not respond to conventional treatments, our findings have implications for future treatment innovation research aiming to target and track whether brain patterns associated with having OCD may change with treatment and/or predict treatment response.Keywords
This publication has 94 references indexed in Scilit:
- High-frequency brain activity and muscle artifacts in MEG/EEG: a review and recommendationsFrontiers in Human Neuroscience, 2013
- A Cortical Core for Dynamic Integration of Functional Networks in the Resting Human BrainNeuron, 2012
- Frequency-dependent functional connectivity within resting-state networks: An atlas-based MEG beamformer solutionNeuroImage, 2012
- Developmental Alterations of Frontal-Striatal-Thalamic Connectivity in Obsessive-Compulsive DisorderJournal of the American Academy of Child & Adolescent Psychiatry, 2011
- Altered Function and Connectivity of the Medial Frontal Cortex in Pediatric Obsessive-Compulsive DisorderBiological Psychiatry, 2010
- The functional role of cross-frequency couplingTrends in Cognitive Sciences, 2010
- Direct Recordings of Pitch Responses from Human Auditory CortexCurrent Biology, 2010
- Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisitedNeuroscience & Biobehavioral Reviews, 2008
- The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey ReplicationMolecular Psychiatry, 2008
- The advantage of combining MEG and EEG: Comparison to fMRI in focally stimulated visual cortexNeuroImage, 2007