Abstract: There is no universal cure in treating patients with COVID-19. Although many countries have announced findings of extrapolation on the COVID-19 vaccine trial, it will be difficult to determine the urgent need for an urgent issue that will likely require several months, including vaccination. At the same time, a strategic, preventive, immune-enhancing approach should be considered to commit to strengthening the immune system to enhance host resistance to infection. Aim: This review article aims to review the current literature to explore scientifically discussed updates that stimulate the immune system as a prevention and treatment for COVID-19, based on its antiviral properties.