Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep: a feasibility study
Open Access
- 1 January 2011
- journal article
- Published by SAGE Publications in Laboratory Animals
- Vol. 45 (1), 50-54
- https://doi.org/10.1258/la.2010.010059
Abstract
Remote telemetric monitoring of fetal haemodynamics in pregnant sheep would allow unrestricted animal movement, minimize suffering and distress, and improve animal welfare, while enhancing the quality of data collected. This may also be useful in clinical practice following fetal surgery. Using an open fetal surgical technique at approximately two-thirds of gestation, we implanted the catheter of a D70-PCTP haemodynamic telemetric device (Data Sciences International, Tilburg, The Netherlands) into the carotid artery of the fetal sheep ( n = 4). The attached transmitter was secured to the posterior aspect of the maternal anterior abdominal wall. Two receivers, with a range of 1 m each, were sited in an 11 m2 sheep enclosure to maximize animal freedom while allowing continuous monitoring of the ewe. The receivers were connected by cable to a nearby computer. In the first two procedures, both fetuses died eight and 12 days after surgery, and the catheter tip was observed to be lying in the bicarotid trunk. In the next two procedures the catheter tip was threaded further upstream from the insertion point, in an attempt to reach the fetal aorta, and both fetuses survived until the scheduled postmortem examination at the end of pregnancy. After catheter implantation, fetal blood pressure (BP) and heart rate (HR) were successfully recorded continuously for seven days and then hourly per day for a further three weeks. The fetal BP and HR values were in the normal range for healthy sheep fetuses.Keywords
This publication has 9 references indexed in Scilit:
- Doppler Ultrasonography for the Noninvasive Measurement of Uterine Artery Volume Blood Flow Through Gestation in the Pregnant SheepReproductive Sciences, 2010
- Feasibility of in utero Telemetric Fetal ECG Monitoring in a Lamb ModelFetal Diagnosis and Therapy, 2008
- Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheepNeuroscience, 2007
- Impact of Continuous Intraoperative Monitoring on Outcomes in Open Fetal SurgeryFetal Diagnosis and Therapy, 2005
- Renal, cardiovascular and endocrine responses of fetal sheep at 0.8 of gestation to an infusion of amino acidsJournal Of Physiology-London, 2002
- The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusionJournal Of Physiology-London, 1999
- Fluid Abnormalities Occur in the Chronically Cannulated Mid-Gestation but Not Late Gestation Ovine FetusPediatric Research, 1998
- Response of Sympatho‐Adrenal Axis and Adrenal Cortex to Short‐Term Restraint Stress in SheepJournal of Veterinary Medicine Series A, 1993
- The effect of heart rate on in utero left ventricular output in the fetal sheep.Journal Of Physiology-London, 1986