Association between premature ovarian insufficiency and gut microbiota
Open Access
- 5 June 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Pregnancy and Childbirth
- Vol. 21 (1), 1-8
- https://doi.org/10.1186/s12884-021-03855-w
Abstract
Background: Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI. Methods: Subjects were recruited at the Shenzhen Maternity & Child Healthcare Hospital. Fecal microbial community profiles of healthy women (n = 18), women with POI (n = 35) were analyzed using 16S rRNA gene sequencing based on Illumina NovaSeq platform. Results: Compared to the controls, the serum levels of FSH, LH, T and FSH/LH ratio significantly increased in women with POI, whereas E2 and AMH decreased significantly. Higher weighted UniFrac value was observed in POI women compared with healthy women. Phylum Firmicutes, genera Bulleidia and Faecalibacterium were more abundant in healthy women, while phylum Bacteroidetes, genera Butyricimonas, Dorea, Lachnobacterium and Sutterella enriched significantly in women with POI. Moreover, these alterations of the gut microbiome in women with POI were closely related to FSH, LH, E2, AMH level and FSH/LH ratio. Conclusions: Women with POI had altered microbial profiles in their gut microbiome, which were associated with serum hormones levels. These results will shed a new light on the pathogenesis and treatment for POI.Funding Information
- Sanming Project of Medicine in Shenzhen (SZSM201612046)
- Guangdong Provincial Administration of Traditional Chinese Medicine (20201294)
- Internal research project of Shenzhen Maternity&Child Healthcare Hospital (FYA2018006)
This publication has 46 references indexed in Scilit:
- Sex hormone replacement in ovarian failure – new treatment conceptsBest Practice & Research Clinical Endocrinology & Metabolism, 2015
- Genitourinary syndrome of menopauseMenopause, 2014
- Premature ovarian insufficiency in young girls: repercussions on uterine volume and bone mineral densityGynecological Endocrinology, 2014
- Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorderMolecular Autism, 2013
- The cardiovascular effects of premature ovarian failureInternational Journal of Cardiology, 2013
- Commensal Clostridia: leading players in the maintenance of gut homeostasisGut Pathogens, 2013
- Resumption of Ovarian Function and Pregnancies in 358 Patients with Premature Ovarian FailureJournal of Clinical Endocrinology & Metabolism, 2011
- Microbiome and MalignancyCell Host & Microbe, 2011
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- Age at Natural Menopause and Cause-specific MortalityAmerican Journal of Epidemiology, 2005