A Concept for a Novel Test for Chemical Parity
Open Access
- 1 January 2018
- journal article
- Published by Scientific Research Publishing, Inc. in Green and Sustainable Chemistry
- Vol. 08 (04), 311-319
- https://doi.org/10.4236/gsc.2018.84021
Abstract
Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.Keywords
This publication has 1 reference indexed in Scilit:
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