The information is the necessary tool for the conscientization of a population, thus, in order to ensure a scientific contribution, this project aimed to investigate the interaction between humans and pets with the advancement of COVID-19 in the municipality of Mossoró - RN. For this, questionnaire was applied through visits at residences in the regions of the city of Mossoró - RN according to the simple random probability sampling method. 496 people participated in the study. The questionnaire contained questions related to the ownership of pets, including whether dogs and cats may transmit Covid-19 to humans, whether there was greater interaction with their pets during the Covid-19 pandemic, whether there was a need for abandonment of dogs and cats during quarantine, if the guardian felt comforted by the presence of the animal, among other data related to human-animal interaction during social isolation. It was observed that more than half of the population has pets, and that these animals served as emotional comfort for their guardians throughout the period of isolation. It was found that there was greater interaction with the animals, and that the abandonment rate during the isolation period was not growing. Thus, it may be concluded that the human-animal interaction was influenced by the Covid-19 pandemic, so that guardians and their animals have strengthened family ties.