PHYSICIAN’S ATTITUDE TOWARDS TREATMENT OF OLDER PATIENTS AND THE CHOICE OF THERAPY
Open Access
- 1 January 2013
- journal article
- Published by Hematology Section, Dept. of Radiological Science and Hematology, Catholic University, Rome, Italy in Mediterranean Journal of Hematology and Infectious Diseases
- Vol. 5 (1), e2013025
- https://doi.org/10.4084/mjhid.2013.025
Abstract
The treatment of acute myeloid leukemia in older patients is still object of controversies, because of considerable heterogeneity of patients and disease. Reluctance in administering conventional intensive chemotherapy relies on life-threatening complications induced by treatment in an often frail patient population. Nonetheless, while there is general consensus on the management of frail patients with supportive care only, a wide area of uncertainty remains for a considerable proportion of patients in whom treatment beyond support is feasible, with the aim of altering the natural history of the disease. Several predictive score have been proposed in order to prevent toxicity in absence of survival advantage, however in the daily practice patients’ and physician attitude do still have a major role in the final therapeutic decision.Keywords
This publication has 34 references indexed in Scilit:
- Acute myeloid leukaemia in adultsThe Lancet, 2013
- Acute myeloid leukemia in the real world: why population-based registries are neededBlood, 2012
- Prediction of Early Death After Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia With Pretreatment Risk Scores: A Novel Paradigm for Treatment AssignmentJournal of Clinical Oncology, 2011
- Hypomethylating agents for the treatment of acute myeloid leukemia in the elderlyCancer, 2011
- Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomesThe Lancet, 2010
- Treatment of older patients with acute myeloid leukaemiaThe Lancet, 2010
- Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigmBlood, 2010
- TREATMENT OF CANCER IN THE OLDER AGED PERSONMediterranean Journal of Hematology and Infectious Diseases, 2010
- Heterogeneity in the therapeutic approach to relapsed elderly patients with acute myeloid leukaemia: a survey from the Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Acute Leukaemia Working PartyHematological Oncology, 2008
- Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survivalLeukemia, 2005