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Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

, Ruth R Hagen, Jet Van Den Dijssel, Lisan H Kuijper, Christine Kreher, , Laura Yl Kummer, Maurice Steenhuis, Mariel Duurland, Rivka de Jongh,
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Published: 15 July 2022
 in Elife

Abstract: Patients affected by different types of autoimmune diseases, including common conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated with immunosuppressants to suppress disease activity. It is not fully understood how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific humoral and cellular immunity induced by infection and/or upon vaccination is affected by immunosuppressants.
Keywords: autoimmune disease / SARS-CoV-2 / immunosuppressant / rheumatoid arthritis / multiple sclerosis / COVID-19 mRNA vaccine / immunity / Human

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