Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273
Open Access
- 15 July 2022
- journal article
- research article
- Published by eLife Sciences Publications, Ltd in eLife
Abstract
Background: Patients affected by different types of autoimmune diseases, including common conditions such as Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA), are often treated with immunosuppressants to suppress disease activity. It is not fully understood how the SARS-CoV-2 specific humoral and cellular immunity induced by infection and/or upon vaccination is affected by immunosuppressants.Funding Information
- ZonMw (#10430072010007)
- European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (#860003)
- European Commission (SUPPORT-E, #101015756)
- European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (#792532)
- NHMRC Leadership Investigator Grant (1173871)
- PPOC (#20_21 L2506)
This publication has 96 references indexed in Scilit:
- Human Ebola virus infection results in substantial immune activationProceedings of the National Academy of Sciences of the United States of America, 2015
- The generation of antibody-secreting plasma cellsNature Reviews Immunology, 2015
- FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry dataCytometry Part A, 2015
- A novel significance score for gene selection and rankingBioinformatics, 2012
- Heterogeneity and plasticity of T helper cellsCell Research, 2009
- Therapeutic B cell depletion impairs adaptive and autoreactive CD4+T cell activation in miceProceedings of the National Academy of Sciences of the United States of America, 2007
- B-cell targeting in rheumatoid arthritis and other autoimmune diseasesNature Reviews Immunology, 2006
- Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid ArthritisThe New England Journal of Medicine, 2004
- Induction of Long-Term Memory CD8+T Cells for Recall of Viral Clearing Responses against Influenza VirusJournal of Virology, 2002
- Diminished Primary and Secondary Influenza Virus-Specific CD8+T-Cell Responses in CD4-Depleted Ig−/−MiceJournal of Virology, 2000