Phylodynamic Dispersal of SARS-CoV-2 Lineages Circulating across Polish–German Border Provinces
Open Access
- 24 April 2022
- Vol. 14 (5), 884
- https://doi.org/10.3390/v14050884
Abstract
Introduction: The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has evolved into a worldwide outbreak, with significant molecular evolution over time. Large-scale phylodynamic studies allow to map the virus spread and inform preventive strategies. Aim: This study investigates the extent of binational dispersal and dynamics of SARS-CoV-2 lineages between seven border provinces of the adjacent countries of Poland and Germany to reconstruct SARS-CoV-2 transmission networks. Methods: Following three pandemic waves from March 2020 to the end of May 2021, we analysed a dataset of 19,994 sequences divided into B.1.1.7|Alpha and non-Alpha lineage groups. We performed phylogeographic analyses using the discrete diffusion models to identify the pathways of virus spread. Results: Based on population dynamics inferences, in total, 673 lineage introductions (95% HPD interval 641–712) for non-Alpha and 618 (95% HPD interval 599–639) for B.1.1.7|Alpha were identified in the area. For non-Alpha lineages, 5.05% binational, 86.63% exclusively German, and 8.32% Polish clusters were found, with a higher frequency of international clustering observed for B.1.1.7|Alpha (13.11% for binational, 68.44% German and 18.45% Polish, p < 0.001). We identified key transmission hubs for the analysed lineages, namely Saxony, West Pomerania and Lower Silesia. Conclusions: Clustering patterns between Poland and Germany reflect the viral variant transmission dynamics at the international level in the borderline area. Tracing the spread of the virus between two adjacent large European countries may provide a basis for future intervention policies in cross-border cooperation efforts against the spread of the pandemics.Keywords
Funding Information
- National Centre for Research and Development (SZPITALE-JEDNOIMIENNE/27/2020)
This publication has 48 references indexed in Scilit:
- SERAPHIM: studying environmental rasters and phylogenetically informed movementsBioinformatics, 2016
- SpreaD3: Interactive Visualization of Spatiotemporal History and Trait Evolutionary ProcessesMolecular Biology and Evolution, 2016
- Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen)Virus Evolution, 2016
- Unifying Viral Genetics and Human Transportation Data to Predict the Global Transmission Dynamics of Human Influenza H3N2PLoS Pathogens, 2014
- Simultaneously reconstructing viral cross-species transmission history and identifying the underlying constraintsPhilosophical Transactions B, 2013
- MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and UsabilityMolecular Biology and Evolution, 2013
- Toward a quantitative understanding of viral phylogeographyCurrent Opinion in Virology, 2011
- Bayesian Phylogeography Finds Its RootsPLoS Computational Biology, 2009
- Bayes FactorsJournal of the American Statistical Association, 1995