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(searched for: "10.5155/eurjchem.3.2.228-234.596")
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Mansour Sulaiman Al-Said, Marwa Galal El-Gazzar, Mostafa Mohammed Ghorab
European Journal of Chemistry, Volume 3, pp 228-234; doi:10.5155/eurjchem.3.2.228-234.596

Abstract: On the account of the reported anticancer activity of 2-pyridone, a new series of ethyl-1,6-dihydropyridine-3-carboxylate (4a-j), 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile (6a-h), 2H-chromene (7,8) and 3H-chromeno[3,4-c]pyridone derivatives (9,10) were synthesized and tested for in-vitro anticancer activity against Ehrlich Ascites Carcinoma (EAC) cell line and human liver cell line (HEPG2). The structures of the synthesized compounds were confirmed by analytical and spectral data. Furthermore, radiosensitization study was performed for the most potent compounds (4a, 4d, 6a, 6c, 6e and 10).
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