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(searched for: "10.5155/eurjchem.3.2.143-146.551")
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Sohail Anjum Shahzada, Zulfiqar Ali Khan, Muhammad Yar, Islam Ullah Khan, Syed Ali Raza Naqvi, Nasir Mahmood, Khalid Mohammed Khan
European Journal of Chemistry, Volume 3, pp 143-146; doi:10.5155/eurjchem.3.2.143-146.551

Abstract: An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC50 12.60 ± 0.92 μM.
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